Explain how cooperativity enhances hemoglobin Oâ‚‚ loading at high Oâ‚‚ concentration and Oâ‚‚ unloading at low Oâ‚‚ concentration and interpret a graph of hemoglobin oxygen binding
a. Hemoglobin binds Oâ‚‚ reversibly, loading Oâ‚‚ on the lungs and unloading it into other parts of the body
b. When Oâ‚‚ binds to one subunit, the other change shape slightly, increasing their affinity for Oâ‚‚
c. A slight change in POâ‚‚ causes hemoglobin to load or unload a substantial amount of Oâ‚‚
d. Low pH decreases the affinity of hemoglobin for Oâ‚‚ (Bohr effect)
