I already answered the first 3, so, I am going to skip to the 4th and 5th.
4. The Ming dynasty slipped into isolation, as a form of protection and security, and because they pretty much had everything they needed. They worried that Europeans might conquer them
5. The Spaniards wiped out many Native Americans by killing them and spreading disease. All traces of Native American culture were wiped out in the Americas.
I hope this helps!
